Overview

As an agonist analog of gonadotropin releasing hormone (GnRH), Triptorelin has been suggested by researchers to bind to the receptors in the pituitary gland which may then stimulate the secretion of luteinizing hormone (LH)  and follicle-stimulating hormone (FSH). This at first may cause an upsurge in the initial phase of LH and FSH stimulation. Later, as the receptors become less sensitive to the compound (i.e., downregulation of the receptors), it may possibly lead to reduced release of LH and FSH.

Scientists consider that reduction in the levels of LH and FSH hormones eventually leads to decrease in testosterone and estrogen levels. This event may lead to the suppression of steroidogenesis by ovaries and testicles.⁽⁵⁾ Researchers suggest that Triptorelin exhibits some potential in sustaining the decline in the LH and FSH secretion.