Overview

Melanotan 2 likely serves as a non-selective agonist with the potential to bind with five different melanocortin receptor subtypes (MC-R). Depending on the localization, the receptor-Melanotan 2 bond may induce different actions. MC1-R and MC2-R, located on the skin and adrenal cortex, are considered melanocytic in nature. If Melanotan 2 binds with these receptors, it may stimulate them and induce melanocytes in the skin. This event may lead to increased production of eumelanin, which causes skin tanning.⁽⁴⁾

MC3-R appears to be located in the brain and digestive tract, and MC5-R in the endocrine and exocrine glands.⁽⁴⁾ MC4-R, finally, is considered to be located in the central nervous system. If Melanotan 2 binds with this receptor, it may induce supraspinal centers in the brain, which may lead to increased libido. These signals may then be carried to the sympathetic and parasympathetic centers in the spinal cord and thoracolumbar region.⁽³⁾