Overview

Epithalon is a synthetic tetrapeptide, also known as AEDG peptide, composed of amino acids Ala-Glu-Asp-Gly.⁽²⁾ The peptide has been suggested to exhibit action similar to Epithalamin via various modes. Epithalamin is a related pineal peptide preparation containing Epithalon, that has been purported to potentially increase the average lifespan of various experimental models by 11–31% and may reduce mortality in murine models by a suggested 52%.⁽³⁾ This potential mechanism and further studies are described below.