Overview

The peptide has been suggested to stimulate the synthesis and release of gonadotropins, the luteinizing hormone, and the follicle-stimulating hormone by possibly stimulating the GnRH receptors in the anterior pituitary gland cells.⁽⁴⁾ This is mainly the reason why Gonadorelin is referred to by researchers as a “GnRH agonist,” as it may possibly induce the same action as GnRH.

Researchers have also suggested that excessive exposure to Gonadorelin may induce the opposite action – namely, the downregulation of GnRH receptors at the pituitary gland. This peptide hormone binds to the receptors, which, for a short period, may at first stimulate the secretion of the gonadotropins. Eventually, scientists believe the receptors become less sensitive towards this peptide, aka downregulation of the receptors, which then reversibly inhibits the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH).⁽⁴⁾ Research on this peptide and other GnRH analogs are underway, and several research hypotheses have been presented, which may be summarized thus:

• Gonadorelin may help researchers meter hypothalamus and pituitary gland functions;
• It may possibly induce ovulation;
• It may be a potential anticarcinogenic agent;
• It may reduce the likelihood of neurological deterioration.

All of these hypotheses are under examination in ongoing scientific research.